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Contraindicated. Coadministration not proposed; strong cytochrome P450 enzyme inducers lower systemic exposure to roflumilast and will lessen the therapeutic usefulnessMonitor Carefully (1)phenobarbital will lower the level or effect of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Loss of, or diminished r